Linked Life Data

3193791

Source:http://linkedlifedata.com/resource/pubmed/id/3193791

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1989-1-10
pubmed:abstractText
The antipyretic activity of two sesquiterpene lactones, beta-santonin and arsubin, isolated from the lipid fraction of Artemisia coerulescens subsp. gallica was determined in rats along with the activity of alpha-santonin. In its alpha- and beta-forms, santonin caused a decrease in the body temperature of rats made febrile by the subcutaneous injection of beer yeast. This decrease, more pronounced in the case of beta-santonin, was dose-dependent and antagonized by pretreatment with haloperidol, an agent that also opposes the antipyretic activity of dopamine. These findings seem to show that the alpha- and beta-forms of santonin act on rectal temperature in a way similar to dopamine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-8741
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
285-90
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Antipyretic activity of alpha- and beta-santonin.
pubmed:affiliation
Laboratory of Pharmacognosy and Pharmacodynamics, Faculty of Pharmacy, University of Salamanca, Spain.
pubmed:publicationType
Journal Article