Linked Life Data

3192279

Source:http://linkedlifedata.com/resource/pubmed/id/3192279

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-1-4
pubmed:abstractText
The humoral antibody response of CAF1 mice to low doses (1-100 micrograms) of egg albumin (EA) encapsulated in or covalently bound to the surface of liposomes was studied for three routes of administration. The liposome immunoadjuvant effect observed was found to depend on the location of the antigen, either on the liposome surface or entrapped inside the liposome, and on the number of immunizations. Following a single immunization, the highest antibody titers were elicited with liposomes having EA conjugated to their surface, regardless of the route of administration. For multiple immunizations given i.v. or i.p. EA conjugated to the surface of liposomes was also superior to either free or liposome-encapsulated EA. However, the antibody response to EA bound to the surface of liposomes was not enhanced as compared to free EA following multiple subcutaneous immunizations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0165-2478
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-64
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Antibody responses to liposome-associated antigen.
pubmed:affiliation
Naval Medical Research Institute, Bethesda, MD 20854.
pubmed:publicationType
Journal Article