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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1989-1-12
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pubmed:abstractText |
The levels of prolactin receptors (PRL-R), based on a new micro-method, estrogen receptors (ER) and progesterone receptors (PG-R), were determined in 159 breast cancer specimens. Sixty-seven of 159 tumors (42%) had PRL-R levels of 20 fmol/mg protein or higher, and were regarded as PRL-R positive. In 60 of the 159 samples (38%), no PRL-R could be detected, and the remaining 32 samples (20%) were considered borderline. While a positive correlation was found between the presence of ER and PGR, no correlation was detected between PRL-R and any steroid receptors (r = -0.024 for ER vs PRL-R, 0.052 for PGR vs PRL-R and 0.002 for ER + PGR vs PRL-R). Furthermore, PRL-R in levels of 20 fmol/mg protein or higher were found in 35% of samples in which no steroid receptors were detected as well as in 38% and in 27% of samples which exhibited positive ER or PGR respectively (greater than or equal to 20 fmol/mg protein). On the other hand, in 47% of the samples possessing both ER and PGR, the PRL receptors could not be found. These results clearly demonstrate that in the human breast cancer, the presence of PRL-R is independent of the status of either ER or PGR. It is suggested that the measurement of PRL-R could serve as a chemical marker to guide a possible therapeutic use of PRL-suppressing drugs in women with breast cancer.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0753-3322
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
327-34
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3191209-Adult,
pubmed-meshheading:3191209-Aged,
pubmed-meshheading:3191209-Aged, 80 and over,
pubmed-meshheading:3191209-Biological Markers,
pubmed-meshheading:3191209-Breast Neoplasms,
pubmed-meshheading:3191209-Female,
pubmed-meshheading:3191209-Humans,
pubmed-meshheading:3191209-Middle Aged,
pubmed-meshheading:3191209-Radioligand Assay,
pubmed-meshheading:3191209-Receptors, Estrogen,
pubmed-meshheading:3191209-Receptors, Progesterone,
pubmed-meshheading:3191209-Receptors, Prolactin
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pubmed:year |
1988
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pubmed:articleTitle |
Lack of relationship between the levels of prolactin receptors and steroid receptors in women with breast cancer.
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pubmed:affiliation |
Endocrine, Polypeptide and Cancer Institute, Veterans' Administration Medical Center, New Orleans, LA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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