Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-12-28
pubmed:abstractText
1. Allopurinol usage in 50 patients of a city teaching hospital was surveyed. 2. The plasma concentrations of oxipurinol and uric acid and the urinary production of uric acid were examined. 3. The daily doses of allopurinol ranged from 50 to 1200 mg but 83% of patients were taking 300 mg daily. 4. A wide range of plasma oxipurinol concentrations was observed from 2.8 to 55.8 mg l-1 with a mean +/- s.d. of 15.2 +/- 11.7 mg l-1. 5. The population studied included a high proportion of patients with renal impairment and creatinine clearance was a significant determinant of oxipurinol concentrations (P less than 0.005). 6. There was no significant correlation between plasma urate and plasma oxipurinol concentrations and only a few plasma urates were above the upper limit of the reference range of the laboratory. 7. It was apparent that many patients were taking unnecessarily high daily doses of allopurinol and that renal status was not always considered when deciding dosage regimens of allopurinol.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3190992-1244564, http://linkedlifedata.com/resource/pubmed/commentcorrection/3190992-3119013, http://linkedlifedata.com/resource/pubmed/commentcorrection/3190992-3607420, http://linkedlifedata.com/resource/pubmed/commentcorrection/3190992-3690140, http://linkedlifedata.com/resource/pubmed/commentcorrection/3190992-3947418, http://linkedlifedata.com/resource/pubmed/commentcorrection/3190992-5658870, http://linkedlifedata.com/resource/pubmed/commentcorrection/3190992-639435, http://linkedlifedata.com/resource/pubmed/commentcorrection/3190992-6691361, http://linkedlifedata.com/resource/pubmed/commentcorrection/3190992-6849735, http://linkedlifedata.com/resource/pubmed/commentcorrection/3190992-762214, http://linkedlifedata.com/resource/pubmed/commentcorrection/3190992-849329
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0306-5251
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
423-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Allopurinol dosage selection: relationships between dose and plasma oxipurinol and urate concentrations and urinary urate excretion.
pubmed:affiliation
Department of Clinical Pharmacology, St Vincent's Hospital, Darlinghurst, Sydney, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't