Linked Life Data

3190456

Source:http://linkedlifedata.com/resource/pubmed/id/3190456

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-12-6
pubmed:abstractText
The synthetic androgen 17 beta-trenbolone (beta-TBOH), used as a growth promotant in cattle, and its metabolite 17 alpha-trenbolone (alpha-TBOH) were tested for genetic toxicity in Syrian hamster embryo (SHE) cells and in mouse C3H10T1/2 embryo fibroblasts by measuring the induction of micronucleus formation and neoplastic cell transformation. Both beta-TBOH and alpha-TBOH, but not testosterone nor its hormonally active metabolite, 5 alpha-dihydrotestosterone, caused a dose-related induction of micronuclei in SHE cells. In C3H10T1/2 cells, neither beta-TBOH nor alpha-TBOH gave rise to micronucleus induction. Furthermore, both beta-TBOH and alpha-TBOH, but not testosterone, were found to transform SHE cells but not C3H10T1/2 cells morphologically. The beta-TBOH-transformed SHE cells proved to be neoplastic in thymus-aplastic nude mice. These data show that beta-TBOH is able to cause changes at the chromosomal level and neoplastic transformation independent of its hormonal activity in one mammalian cell system but not in another one. The implications of these data for the risk evaluation of beta-TBOH are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0340-5761
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-53
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Trenbolone induces micronucleus formation and neoplastic transformation in Syrian hamster embryo fibroblasts but not in mouse C3H10T1/2 cells.
pubmed:affiliation
Institute of Pharmacology and Toxicology, University of Würzburg, Federal Republic of Germany.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't