Linked Life Data

3190441

Source:http://linkedlifedata.com/resource/pubmed/id/3190441

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-12-16
pubmed:abstractText
Sodium chromate (20 mg/kg, s.c.), which in male rats inflicted necrotic damage mainly in the P1 region (proximal part of the proximal convoluted tubules), protected against proximal tubular necrosis induced by 0.5 or 3.0 mg Hg2+/kg in the P2 (distal part of the proximal convoluted tubules) and P3 (pars recta part of the proximal tubules) regions. Histochemical staining for mercury indicated that chromate increased mercury deposition in those cells of the P1 region which were unaffected by chromate (had intact brush border) but did not decrease mercury deposition in the most severely affected P3 region. Chromate pretreatment actually increased mercury deposition in the kidneys of animals killed 24 h after the injection of 0.5 mg Hg2+. The protective effect was mutual. Cellular proliferation and fibrosis observed 4-5 days after chromate were prevented by injecting 0.5 mg Hg2+/kg 3 days after chromate treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-5761
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
440-3
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
The effect of sodium chromate pretreatment on mercuric chloride-induced nephrotoxicity.
pubmed:affiliation
Life Science Research, Elm Farm Laboratories Occold, Nr. Eye, Suffolk, United Kingdom.
pubmed:publicationType
Journal Article