Linked Life Data

3189575

Source:http://linkedlifedata.com/resource/pubmed/id/3189575

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 2
pubmed:dateCreated
1988-12-14
pubmed:abstractText
Regional left ventricular systolic pressure-thickness relations have been used to assess regional load-insensitive contractility with the assumption that they possess linear isochrones that are fundamental to the time-varying elastance model of global pressure-volume relations. We examined the shape and time-varying behavior of pressure-thickness isochrones in six open-chest canine preparations. Transmural wall thickening (sonomicrometry) and ventricular pressure were altered by abrupt preload alterations during control, dobutamine, and propranolol. In all dogs and interventions, linear isochrones (r2 mean +/- SE = 0.91 +/- 0.11) were found at 5-ms intervals. During control, linear isochrone slope rose monotonically from onset to end of systole. Thickness-axis intercepts also varied continuously in time, but peak intercept and maximal slope were asynchronous. Dobutamine caused a steeper earlier maximum slope and increased slope-intercept asynchrony. Propranolol reduced maximum slope and slope-intercept asynchrony. Isochronal data during early systole were better fitted to a parabolic than to the linear model; however, fits to linear and parabolic models were equally good near end of systole. Linear isochronal behavior exists in systolic pressure-thickness relations especially near end systole and is maintained during modest inotropic alterations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
255
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H1136-43
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Isochronal behavior in left ventricular systolic pressure-wall thickness relations.
pubmed:affiliation
Department of Internal Medicine (Cardiology), Medical College of Virginia, Richmond.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't