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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1988-12-14
|
| pubmed:abstractText |
In the present investigation we studied serum anti-thyroglobulin and anti-thyroid microsomal autoantibodies, measured by hemagglutination technique, in 600 patients with thyroid cancer seen by us from 1975 to 1985 (mean follow-up 46 months). Positive thyroglobulin antibodies and/or microsomal antibodies were found in 138 (23%) patients (23.9% with papillary, 25% with follicular, 16.1% with anaplastic, and 4.1% with medullary thyroid carcinomas). The incidence of positive tests was similar in each decade of life (ranging between 21.9% and 27.9%), whereas in a normal sex-matched population with no evidence of thyroid disease, the frequency of positive tests was very low in young people and increased to 23% in people older than 60. In 64 patients with no evidence of residual or metastasic thyroid tissue after surgery and radioiodine, initially positive antibody titres became negative in 54.6%, decreased in 32.8%, did not change in 3.1%, and increased in 9.3%. On the contrary, antibody titres of patients with persistent disease became undetectable in 8.3%, decreased in 16.6%, remained unchanged in 25%, and increased in 50%. The clinical course of differentiated thyroid cancer was unaffected by the presence of thyroid antibodies and no difference was found in the death rate between antibody-positive and antibody-negative patients (11.5% and 13.6%, respectively). In conclusion, our data indicate that: 1) autoimmune phenomena are not an infrequent finding in thyroid cancer; 2) as in non-malignant thyroid diseases, positive-antibody tests are more frequently observed in females than in males; 3) at variance with normal controls, no age-dependent increase in serum anti-thyroid antibodies was found in thyroid cancer; 4) the presence of metastatic thyroid tissue seems to be necessary to perpetuate the autoantibody synthesis, and 5) anti-thyroid autoantibodies are not a protective or worsening factor in the tumour outcome.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0001-5598
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
119
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
373-80
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3188810-Adolescent,
pubmed-meshheading:3188810-Adult,
pubmed-meshheading:3188810-Age Factors,
pubmed-meshheading:3188810-Aged,
pubmed-meshheading:3188810-Autoantibodies,
pubmed-meshheading:3188810-Carcinoma,
pubmed-meshheading:3188810-Carcinoma, Papillary,
pubmed-meshheading:3188810-Child,
pubmed-meshheading:3188810-Female,
pubmed-meshheading:3188810-Follow-Up Studies,
pubmed-meshheading:3188810-Humans,
pubmed-meshheading:3188810-Male,
pubmed-meshheading:3188810-Microsomes,
pubmed-meshheading:3188810-Middle Aged,
pubmed-meshheading:3188810-Prognosis,
pubmed-meshheading:3188810-Sex Factors,
pubmed-meshheading:3188810-Thyroglobulin,
pubmed-meshheading:3188810-Thyroid Gland,
pubmed-meshheading:3188810-Thyroid Neoplasms
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Thyroid autoantibodies in thyroid cancer: incidence and relationship with tumour outcome.
|
| pubmed:affiliation |
Cattedra di Endocrinologia e Medicina Costituzionale, University of Pisa, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|