Linked Life Data

3188599

Source:http://linkedlifedata.com/resource/pubmed/id/3188599

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-12-21
pubmed:abstractText
12 pregnant women with premature labor received tocolytic treatment with clenbuterol tablets. Initially, 2 clenbuterol tablets (40 micrograms each) were to be given as loading dose (application interval = 12 hours), then a dose reduction was planned (40 micrograms), to be followed by a maintenance dose of 20 micrograms. The mean values of plasma levels of clenbuterol hydrochloride during the day ranged between 0.266 and 0.328 ng/ml on testing days 2 to 8, without significant statistical variation. Therefore, the loading dose lead to the desired rapid steady state of the plasma level. The applied dosage plan with clenbuterol tablets for oral therapy of premature labor proved to be ideal, both clinically as well as pharmacokinetically. After reaching an effective plasma level, only 20 micrograms b.i.d. is sufficient as maintenance dose, resulting in excellent patient compliance compared with oral fenoterol therapy (max. application interval: 4 hours).
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-967X
pubmed:author
pubmed:issnType
Print
pubmed:volume
192
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
158-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Oral tocolytic therapy with clenbuterol--determination of the plasma level].
pubmed:affiliation
Geburtshilflich-Gynäkologische Abteilung, St. Lukas Klinik Solingen.
pubmed:publicationType
Journal Article, English Abstract