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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1977-2-16
|
| pubmed:abstractText |
Transvenous right ventricular pacemaker catheters were implanted in 18 mongrel dogs for periods of 2 to 18 months (average 4.9 months). Heart block was produced in 15 of these dogs by injection of 37 per cent formaldehyde into the interatrial septum. In the other three dogs which served as controls, no heart block was produced and no electrical stimulation was applied to the implanted catheters. After the animals had been put to death, gross and microscopic examination of the hearts revealed four categories of morphological changes: (1) connective tissue sheath formation around the catheters, (2) endocardial papillary thickening, (3) interatrial septal changes, and (4) myocardial damage. Changes 1, 2, and 4 occurred in one or more intracardiac locations in all 18 dogs. Change 3 occurred only in the 15 dogs in which heart block was produced. The most striking histologic findings were areas of cartilagenous metaplasia in endocardium an underlying myocardium and areas of marked cellular proliferation of the endocardial cells both in the endothelium and underlying stroma. Chronic implantation of transvenous intracardiac pacemaker catheters in dogs consistently produces morphologic changes which may interfere with cardiac and pacemaker function and may hinder attempts to remove nonfunctional or unneeded catheter electrodes. The changes observed appear to be related to the presence of foreign material per se and not external electrical stimulation of the heart.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0002-8703
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
93
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
73-81
|
| pubmed:dateRevised |
2006-2-27
|
| pubmed:meshHeading |
pubmed-meshheading:318794-Animals,
pubmed-meshheading:318794-Connective Tissue,
pubmed-meshheading:318794-Disease Models, Animal,
pubmed-meshheading:318794-Dogs,
pubmed-meshheading:318794-Endocardium,
pubmed-meshheading:318794-Foreign-Body Reaction,
pubmed-meshheading:318794-Heart Block,
pubmed-meshheading:318794-Heart Catheterization,
pubmed-meshheading:318794-Heart Septum,
pubmed-meshheading:318794-Hyperplasia,
pubmed-meshheading:318794-Myocardium,
pubmed-meshheading:318794-Pacemaker, Artificial,
pubmed-meshheading:318794-Tricuspid Valve
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Cardiac pathology of transvenous pacemakers in dogs.
|
| pubmed:publicationType |
Journal Article
|