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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
1988-12-22
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pubmed:databankReference |
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pubmed:abstractText |
We have analyzed the molecular genetics of the breakpoints involved in the t(8;14) and t(14;18) translocations of an acute pre-B-cell leukemia from a patient with a history of follicular lymphoma. In this patient's leukemic cells, the breakpoint of the t(14;18) translocation occurred in the major breakpoint-cluster region of the BCL2 gene and became linked to the JH4 joining-region gene segment of the immunoglobulin heavy-chain locus on the 14q+ chromosome as previously observed in follicular lymphoma. An N region and heptamer and nonamer signal sequences indicated that this translocation occurred as a mistake in VH-DH-JH joining (where VH and DH are the variable and diversity segments). In the t(8;14) translocation, the breakpoint was located immediately 5' of the first exon of the MYC protooncogene, which was juxtaposed with the C gamma 2 constant gene segment of the second 14q+ chromosome. The finding of repeated sequences typical of switch regions suggested that this translocation occurred during heavy-chain isotype switching, resulting in progression to pre-B-cell leukemia with both the t(8;14) and the t(14;18) translocations. The terminal deoxynucleotidyltransferase-positive phenotype of the patient's leukemic cells further suggests that the pre-B-cell leukemia was derived from a pre-B cell carrying a t(14;18) translocation in the original follicular lymphoma. The polymerase chain reaction method was then used to identify cancer cells in the bone marrow of the patient.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-2448875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3033665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3104914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3129686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3131717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3285208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3458257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3495396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3540591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3547408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3607281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3874430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3921823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-3924412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-4113130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6092963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6093263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6101209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6319017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6324175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6334305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6419122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6419123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6714223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6777778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6806666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6808505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6813863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6817141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-6961453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3186743-7133054
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8548-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3186743-Base Sequence,
pubmed-meshheading:3186743-Blotting, Southern,
pubmed-meshheading:3186743-Bone Marrow,
pubmed-meshheading:3186743-Cell Transformation, Neoplastic,
pubmed-meshheading:3186743-Chromosomes, Human, Pair 14,
pubmed-meshheading:3186743-Cloning, Molecular,
pubmed-meshheading:3186743-Gene Expression Regulation,
pubmed-meshheading:3186743-Humans,
pubmed-meshheading:3186743-Leukemia, B-Cell,
pubmed-meshheading:3186743-Molecular Sequence Data,
pubmed-meshheading:3186743-Nucleic Acid Hybridization,
pubmed-meshheading:3186743-Oncogenes,
pubmed-meshheading:3186743-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:3186743-Preleukemia,
pubmed-meshheading:3186743-Restriction Mapping
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pubmed:year |
1988
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pubmed:articleTitle |
Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene.
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pubmed:affiliation |
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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