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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1988-12-22
|
| pubmed:abstractText |
An increase in serum iron levels and a decrease in serum unsaturated iron binding capacity (uIBC) were noted following the administration of cisplatinum to 9 children with malignancies. The mean serum iron concentration increased from a pretreatment level of 75.7 +/- 30.5 micrograms/ml to a posttreatment level of 162.1 +/- 65.3 micrograms/ml with the first cisplatinum treatment course (p less than 0.004). The uIBC concomitantly decreased from 181.9 +/- 33.7 micrograms/ml to 86.4 +/- 44.6 micrograms/ml (p less than 0.0005). A cumulative effect was noted following subsequent courses. The levels returned to baseline values within 2-4 months following cessation of therapy in 6 children in whom follow-up data were available. It is possible that this reversal of the iron/uIBC ratio is the result of cisplatinum competition for iron binding sites to proteins.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0030-2414
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
421-3
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading | |
| pubmed:year |
1988
|
| pubmed:articleTitle |
Elevated serum iron levels following administration of cisplatinum.
|
| pubmed:affiliation |
Department of Pediatrics, University of Mississippi Medical Center, Jackson.
|
| pubmed:publicationType |
Journal Article
|