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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1976-4-15
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pubmed:abstractText |
27 Sprague-Dawley rats were anesthetized with pentobarbital. Artificial ventilation was given by a Starling pump respirator via a tracheal tube. Intracellular pH of cardiac muscle was determined by means of the indirect procedure of measuring the distribution of 5,5-dimethyl-2,4-oxazolidinedione (DMO) in intra- and extracellular spaces (DMO-method). 12 rats were injected i.p. with 0.33 mval potassium-magnesium-aspartate/100 g body weight and 15 rats served as controls. Using a regression analysis, the following relationships were obtained: 1. animals injected with potassium-magnesium-aspartate pHa = --0.75 log PaCO2 + 8.535, PHi = --0.30 log PaCO2 + 7.509, pHi = 0.41 pHa + 4.036; 2. control animals pHa = --0.59 log PaCO2 + 8.308, pHi = --0.27 log PaCO2 + 7.381, pHi = 0.47 pHa + 3.503. At a pCO2 of 40 torr a pHa of 7.33 (7.36) and a pHi of 7.03 (6.95) was obtained. At an arterial pH of 7.40 the pHi was 7.07 (6.98). The results of the control group are written in brackets. -- The experiments demonstrate an increase in the intracellular buffer bases after administration of potassium-magnesium-aspartate. This effect can be recognized by a concomitant increase in the intracellular pH of 0.09 compared to the control group.
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pubmed:language |
ger
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Bicarbonates,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Dioxide,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Magnesium,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium
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pubmed:status |
MEDLINE
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pubmed:issn |
0004-4172
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1897-900
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3185-Animals,
pubmed-meshheading:3185-Aspartic Acid,
pubmed-meshheading:3185-Bicarbonates,
pubmed-meshheading:3185-Body Weight,
pubmed-meshheading:3185-Carbon Dioxide,
pubmed-meshheading:3185-Extracellular Space,
pubmed-meshheading:3185-Heart,
pubmed-meshheading:3185-Hematocrit,
pubmed-meshheading:3185-Hemoglobins,
pubmed-meshheading:3185-Hydrogen-Ion Concentration,
pubmed-meshheading:3185-Intracellular Fluid,
pubmed-meshheading:3185-Magnesium,
pubmed-meshheading:3185-Male,
pubmed-meshheading:3185-Myocardium,
pubmed-meshheading:3185-Oxygen,
pubmed-meshheading:3185-Potassium,
pubmed-meshheading:3185-Rats
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pubmed:year |
1975
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pubmed:articleTitle |
[Intracellular pH of cardiac muscle after administration of potassium-magnesium-aspartate (author's transl)].
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pubmed:publicationType |
Journal Article,
English Abstract
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