Linked Life Data

3184850

Source:http://linkedlifedata.com/resource/pubmed/id/3184850

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-12-5
pubmed:abstractText
Chloralose is an intravenous anesthetic which preserves vagal and central baroreceptor reflexes, thus rendering it useful for physiologic research. However, chloralose is recommended for terminal experiments only, due to concerns relating to long-term toxicity. We investigated the safety of chloralose in longitudinal pulmonary function studies in beagle puppies. Twelve puppies received chloralose anesthesia repeatedly (8-12 times per dog) between the ages of 80 and 300 days. Constant anesthetic depth was maintained reliably throughout the course of the experiments. Recovery lasted approximately 4 hours in each experiment and occurred in four definable stages. Following recovery, the puppies exhibited normal health and growth as compared with other colony animals. There was no biochemical evidence of acute renal, hepatic, pancreatic or cardiac toxicity prior to and immediately after anesthesia, and no evidence of chronic toxicity following completion of the study protocol, after a total cumulative dose of 1.18 g/kg chloralose. These studies demonstrate that intravenous chloralose is a safe anesthetic for longitudinal use.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0023-6764
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
422-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Intravenous chloralose is a safe anesthetic for longitudinal use in beagle puppies.
pubmed:affiliation
Department of Pediatrics, University of Arizona College of Medicine, Tucson 85724.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.