| pubmed-article:3182532 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3182532 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:3182532 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:3182532 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3182532 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:3182532 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:3182532 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3182532 | pubmed:dateCreated | 1988-12-6 | lld:pubmed |
| pubmed-article:3182532 | pubmed:abstractText | We examined the mechanisms of platelet uptake in the lungs after alpha-thrombin-induced pulmonary microembolism. Platelets labeled with 111In-oxine were reinfused into chronically prepared sheep. Pulmonary microembolism resulted in an increase in lung platelet radioactivity (95.5 +/- 15.3%; n = 4), which was followed by an exponential washout (half-life = 115 +/- 4 min). Platelet uptake in the lungs was more sustained after prior fibrinolytic inhibition with tranexamic acid (half-life = 178 +/- 11 min), although the initial increase was similar (90.7 +/- 9.6%; n = 7). Prior depletion of fibrinogen with ancrod (Arvin), blunted the initial increase in lung platelet uptake after alpha-thrombin challenge (31.7 +/- 11.3%, n = 5), indicating that the effect of thrombin was markedly dependent on fibrinogen. We examined the role of circulating granulocytes, since platelets may bind to subendothelial matrix exposed after granulocyte-mediated lung vascular injury. Maximal pulmonary platelet uptake after thrombin in granulocytopenic sheep was not different from control (71.7 +/- 14.4%; n = 4). The results indicate that pulmonary microembolism results in lung platelet sequestration. Platelet uptake is not dependent on granulocyte-mediated vascular injury but requires fibrin deposition and is sustained if fibrinolysis is inhibited. | lld:pubmed |
| pubmed-article:3182532 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3182532 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3182532 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3182532 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3182532 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3182532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3182532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3182532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3182532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3182532 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3182532 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3182532 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:3182532 | pubmed:author | pubmed-author:KaplanJ EJE | lld:pubmed |
| pubmed-article:3182532 | pubmed:author | pubmed-author:MalikA BAB | lld:pubmed |
| pubmed-article:3182532 | pubmed:author | pubmed-author:CooperJ AJA | lld:pubmed |
| pubmed-article:3182532 | pubmed:author | pubmed-author:McCandlessB... | lld:pubmed |
| pubmed-article:3182532 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3182532 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:3182532 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3182532 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3182532 | pubmed:pagination | 1716-22 | lld:pubmed |
| pubmed-article:3182532 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3182532 | pubmed:meshHeading | pubmed-meshheading:3182532-... | lld:pubmed |
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| pubmed-article:3182532 | pubmed:meshHeading | pubmed-meshheading:3182532-... | lld:pubmed |
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| pubmed-article:3182532 | pubmed:meshHeading | pubmed-meshheading:3182532-... | lld:pubmed |
| pubmed-article:3182532 | pubmed:meshHeading | pubmed-meshheading:3182532-... | lld:pubmed |
| pubmed-article:3182532 | pubmed:meshHeading | pubmed-meshheading:3182532-... | lld:pubmed |
| pubmed-article:3182532 | pubmed:meshHeading | pubmed-meshheading:3182532-... | lld:pubmed |
| pubmed-article:3182532 | pubmed:meshHeading | pubmed-meshheading:3182532-... | lld:pubmed |
| pubmed-article:3182532 | pubmed:meshHeading | pubmed-meshheading:3182532-... | lld:pubmed |
| pubmed-article:3182532 | pubmed:meshHeading | pubmed-meshheading:3182532-... | lld:pubmed |
| pubmed-article:3182532 | pubmed:meshHeading | pubmed-meshheading:3182532-... | lld:pubmed |
| pubmed-article:3182532 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3182532 | pubmed:articleTitle | Determinants of platelet kinetics: effects of pulmonary microembolism. | lld:pubmed |
| pubmed-article:3182532 | pubmed:affiliation | Department of Radiology, Albany Medical College, Union University, New York 12208. | lld:pubmed |
| pubmed-article:3182532 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3182532 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3182532 | lld:pubmed |
