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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1988-12-6
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pubmed:abstractText |
We examined the mechanisms of platelet uptake in the lungs after alpha-thrombin-induced pulmonary microembolism. Platelets labeled with 111In-oxine were reinfused into chronically prepared sheep. Pulmonary microembolism resulted in an increase in lung platelet radioactivity (95.5 +/- 15.3%; n = 4), which was followed by an exponential washout (half-life = 115 +/- 4 min). Platelet uptake in the lungs was more sustained after prior fibrinolytic inhibition with tranexamic acid (half-life = 178 +/- 11 min), although the initial increase was similar (90.7 +/- 9.6%; n = 7). Prior depletion of fibrinogen with ancrod (Arvin), blunted the initial increase in lung platelet uptake after alpha-thrombin challenge (31.7 +/- 11.3%, n = 5), indicating that the effect of thrombin was markedly dependent on fibrinogen. We examined the role of circulating granulocytes, since platelets may bind to subendothelial matrix exposed after granulocyte-mediated lung vascular injury. Maximal pulmonary platelet uptake after thrombin in granulocytopenic sheep was not different from control (71.7 +/- 14.4%; n = 4). The results indicate that pulmonary microembolism results in lung platelet sequestration. Platelet uptake is not dependent on granulocyte-mediated vascular injury but requires fibrin deposition and is sustained if fibrinolysis is inhibited.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
8750-7587
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1716-22
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3182532-Animals,
pubmed-meshheading:3182532-Blood Platelets,
pubmed-meshheading:3182532-Blood Pressure,
pubmed-meshheading:3182532-Cardiac Output,
pubmed-meshheading:3182532-Fibrinogen,
pubmed-meshheading:3182532-Half-Life,
pubmed-meshheading:3182532-Indium Radioisotopes,
pubmed-meshheading:3182532-Kinetics,
pubmed-meshheading:3182532-Lung,
pubmed-meshheading:3182532-Pulmonary Artery,
pubmed-meshheading:3182532-Pulmonary Embolism,
pubmed-meshheading:3182532-Sheep,
pubmed-meshheading:3182532-Spleen,
pubmed-meshheading:3182532-Thrombin,
pubmed-meshheading:3182532-Tranexamic Acid,
pubmed-meshheading:3182532-Vascular Resistance
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pubmed:year |
1988
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pubmed:articleTitle |
Determinants of platelet kinetics: effects of pulmonary microembolism.
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pubmed:affiliation |
Department of Radiology, Albany Medical College, Union University, New York 12208.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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