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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1988-12-7
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pubmed:abstractText |
Two new beta-lactams have been isolated from strains of Serratia and Erwinia sp. and identified as (3R,5R)- and (3S,5R)-carbapenam-3-carboxylic acid. These novel carbapenams lack antibacterial activity, are resistant to both beta-lactamases I and II from Bacillus cereus and are not detected by the lactamase induction assay. Radiolabelled and stable isotope experiments have established that both metabolites together with the antibiotic 5R-carbapenem-3-carboxylic acid are glutamate and acetate derived. A number of possible pathways for the biosynthesis of these compounds as well as their relationship to the more complex members of the carbapenem family of beta-lactam antibiotics are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1231-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3182403-Acetates,
pubmed-meshheading:3182403-Anti-Bacterial Agents,
pubmed-meshheading:3182403-Carbapenems,
pubmed-meshheading:3182403-Carbon Isotopes,
pubmed-meshheading:3182403-Carbon Radioisotopes,
pubmed-meshheading:3182403-Chemical Phenomena,
pubmed-meshheading:3182403-Chemistry,
pubmed-meshheading:3182403-Chromatography, High Pressure Liquid,
pubmed-meshheading:3182403-Glutamates,
pubmed-meshheading:3182403-Lactams,
pubmed-meshheading:3182403-Serratia,
pubmed-meshheading:3182403-Stereoisomerism
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pubmed:year |
1988
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pubmed:articleTitle |
The biosynthetic implications of acetate and glutamate incorporation into (3R,5R)-carbapenam-3-carboxylic acid and (5R)-carbapen-2-em-3-carboxylic acid by Serratia sp.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, University of Nottingham, UK.
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pubmed:publicationType |
Journal Article
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