Linked Life Data

3181293

Source:http://linkedlifedata.com/resource/pubmed/id/3181293

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-12-1
pubmed:abstractText
The centrally acting anticholinesterase drug tacrine has been shown to block K+ channels in guinea pig left atrium. It competitively blocks the negative inotropic effects of adenosine, 2-chloroadenosine and carbachol. Ka values obtained from dose ratio plots were 2.5, 3.5 and 2.9 microM respectively. It was also able to antagonize the shortening of the action potential due to these compounds. Doses of tacrine ranging from 1 to 4 microM restored the AP configuration close to control values. Tacrine also antagonized the binding of 1-quinuclidinyl[phenyl-4-3H]benzilate ([3H]QNB) to membranes derived from the atrium and cerebral cortex. Ki values of 1.8 +/- 0.33 and 1.3 +/- 0.47 microM were obtained respectively. Tacrine was a weak competitor of [3H]phenylisopropyladenosine ([3H]L-PIA) binding in brain membranes. Its diverse pharmacological effects may be relevant to its use in Alzheimer's disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-65
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Blockade of a cardiac K+ channel by tacrine: interactions with muscarinic and adenosine receptors.
pubmed:affiliation
Materials Research Laboratory, Defence Science and Technology Organization, Melbourne, Victoria, Australia.
pubmed:publicationType
Journal Article, In Vitro