Linked Life Data

318127

Source:http://linkedlifedata.com/resource/pubmed/id/318127

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1987-1-6
pubmed:abstractText
In chronic experimental myasthenia gravis (EAMG) in rat, the decrement of electrical and mechanical responses evoked by maximal repetitive (3-167/sec) stimuli to the nerve was greater in the slow-twitch soleus (SOL) than in the fast-twitch extensor digitorum longus (EDL) muscle. Excitation-contraction coupling was impaired in moderate to severe EAMG, as evidenced by a diminished staircase phenomenon and by diminished posttetanic potentiation (PTP) of twitch tension in two EDLs. The only morphologic abnormality observed was an increase in length of the endplates in the EDLs of those animals that had had an acute phase of EAMG. The latter had more than a 90% reduction in the amplitude of the action potential and in the twitch tension of the EDL when stimuli were applied to the nerve. Stimuli applied directly to the muscle evoked a tetanic tension that was one-third of normal. The staircase and PTP were normal. Necrosis occurred in the endplate and in the adjacent segment of muscle fiber; outside the endplate region, the muscle fiber was normal.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0148-639X
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
435-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Experimental autoimmune myasthenia gravis in the rat: a preliminary report.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't