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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1988-12-14
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pubmed:abstractText |
Ca2+ and Zn2+ prevent antibody-dependent complement-induced permeability changes in tonsil lymphocytes and Lettre cells. Lactate dehydrogenase leaks out from Lettre cells at high complement:cell ratios, under which conditions higher concentrations of Ca2+ and Zn2+ are required for protection. Ca2+ and Zn2+ do not inhibit complement activation or C9 binding to Lettre cells, and prevent leakage through preformed lesions. It is concluded that the extent of complement-induced membrane damage depends on the concentration of extracellular Ca2+, and may be modulated by changes in extracellular Ca2+ or Zn2+.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0253-5076
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
141-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3180740-Animals,
pubmed-meshheading:3180740-Calcium,
pubmed-meshheading:3180740-Cell Membrane Permeability,
pubmed-meshheading:3180740-Cell Survival,
pubmed-meshheading:3180740-Cells, Cultured,
pubmed-meshheading:3180740-Complement C3,
pubmed-meshheading:3180740-Complement C9,
pubmed-meshheading:3180740-Complement Inactivator Proteins,
pubmed-meshheading:3180740-Complement System Proteins,
pubmed-meshheading:3180740-Hemolysis,
pubmed-meshheading:3180740-Lymphocytes,
pubmed-meshheading:3180740-Mice,
pubmed-meshheading:3180740-Zinc
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pubmed:year |
1988
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pubmed:articleTitle |
Protection against complement-mediated cell damage by Ca2+ and Zn2+.
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pubmed:affiliation |
Nuffield Department of Pathology, John Radcliffe Hospital, Oxford, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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