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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1988-12-9
|
| pubmed:abstractText |
One of 6 newly synthesized triazinium zwitterions (JR-1--JR-6) was shown to induce 51Cr-release from leukemic (HL60 and CEM) and solid tumor (MM170 and HeLa) cell-lines. Leukemic cells were more sensitive to this compound than solid tumors as demonstrated by dose-response and time-course studies. Other experiments showed that JR-6 (1-methyl-3-phenyl-1,2,4-triazinium-5-olate) significantly suppressed protein, RNA and DNA synthesis at tumoricidal concentrations.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0304-3835
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
29-35
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3180036-Antineoplastic Agents,
pubmed-meshheading:3180036-Cell Division,
pubmed-meshheading:3180036-Cell Line,
pubmed-meshheading:3180036-Cell Survival,
pubmed-meshheading:3180036-Drug Screening Assays, Antitumor,
pubmed-meshheading:3180036-HeLa Cells,
pubmed-meshheading:3180036-Humans,
pubmed-meshheading:3180036-Leukemia,
pubmed-meshheading:3180036-Melanoma,
pubmed-meshheading:3180036-Triazines,
pubmed-meshheading:3180036-Tumor Cells, Cultured
|
| pubmed:articleTitle |
1-Methyl-3-phenyl-1,2,4-triazinium-5-olate: a new zwitterion with cytotoxic activity against human cancer cell-lines.
|
| pubmed:affiliation |
Department of Child Health, Mater Children's Hospital, South Brisbane, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|