Linked Life Data

3179611

Source:http://linkedlifedata.com/resource/pubmed/id/3179611

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-12-21
pubmed:abstractText
1. The mechanism of the flushing, hypotension and tachycardia associated with i.v. administration of desGlyd(CH2)5D-Tyr(Et)VAVP (SK&F 101926; 25 micrograms kg-1) and the selective V2 antidiuretic agonist, desamino-8-D-arginine vasopressin (dDAVP; 3 micrograms kg-1) was studied in ketamine-anaesthetized rhesus monkeys. 2. The flushing associated with SK&F 101926 was reduced by pretreatment with a mast cell stabilizer and by repeated administration of peptide (within 2-4 weeks). A similar desensitization to dDAVP-associated flushing was observed on repeated administration. 3. Treatment with dDAVP also resulted in reduced SK&F 101926-associated flushing. 4. The hypotension associated with SK&F 101926 was not affected by pretreatment with a mast cell stabilizer. A similar degree of hypotension was observed with repeated administration of either SK&F 101926 or dDAVP. 5. The tachycardia associated with SK&F 101926 was reduced by pretreatment with a mast cell stabilizer or repeated administration of SK&F 101926. Repeated administration of dDAVP, however, resulted in an enhanced tachycardia. 6. Indomethacin (5 mg kg-1 i.v.) did not alter the flushing or the hypotension associated with the administration of either SK&F 101926 or dDAVP, but resulted in an enhanced tachycardia to SK&F 101926. 7. Administration of a selective V1 vasopressor antagonist did not result in flushing, hypotension or tachycardia. 8. It was concluded that the flushing response to vasopressin-like peptides in rhesus monkeys may be due to an action on mast cells, whereas the haemodynamic responses are not, but probably involve direct vasodilator actions.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-2948008, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-3514728, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-3519005, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-3598903, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-3754791, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-3791864, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-6217968, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-6400119, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-6426080, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-6547112, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-6712873, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-67283, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-6808693, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-6970907, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-83359, http://linkedlifedata.com/resource/pubmed/commentcorrection/3179611-91929
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
759-64
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Flushing and haemodynamic responses to vasopressin peptides in the rhesus monkey.
pubmed:affiliation
Department of Pharmacology, Smith Kline & French Laboratories, King of Prussia, PA.
pubmed:publicationType
Journal Article