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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
1988-11-22
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pubmed:abstractText |
Physiologically-based pharmacokinetic (PB-PK) models provide a mechanism for reducing the uncertainty inherent in extrapolating the results of animal toxicity tests to man. This paper discusses a technique for incorporating data from in vitro studies of xenobiotic metabolism into in vivo PB-PK models. Methylene chloride is used as an example, and carcinogenic risk estimates incorporating PB-PK principles are presented.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0378-4274
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-116
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3176073-Animals,
pubmed-meshheading:3176073-Cricetinae,
pubmed-meshheading:3176073-Cytosol,
pubmed-meshheading:3176073-Glutathione Transferase,
pubmed-meshheading:3176073-Humans,
pubmed-meshheading:3176073-Hydrocarbons, Chlorinated,
pubmed-meshheading:3176073-Liver,
pubmed-meshheading:3176073-Lung,
pubmed-meshheading:3176073-Methylene Chloride,
pubmed-meshheading:3176073-Mice,
pubmed-meshheading:3176073-Microsomes,
pubmed-meshheading:3176073-Mixed Function Oxygenases,
pubmed-meshheading:3176073-Models, Biological,
pubmed-meshheading:3176073-Neoplasms, Experimental,
pubmed-meshheading:3176073-Rats,
pubmed-meshheading:3176073-Risk Factors,
pubmed-meshheading:3176073-Xenobiotics
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pubmed:year |
1988
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pubmed:articleTitle |
Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PB-PK) model for methylene chloride: implications for risk assessment.
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pubmed:affiliation |
Dow Chemical Company, Health and Environmental Sciences, Midland, MI 48674.
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pubmed:publicationType |
Journal Article,
In Vitro
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