|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-3
|
|
pubmed:dateCreated |
1988-11-22
|
|
pubmed:abstractText |
A model for carcinogenesis is presented that incorporates two features: (1) transition of target stem cells into cancer cells via an intermediate stage in two irreversible steps, and (2) growth and differentiation of normal target and intermediate cells. Implications of the model for initiation-promotion and environmental carcinogenesis are considered.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0378-4274
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
43
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
139-50
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:3176062-Animals,
pubmed-meshheading:3176062-Carcinogens,
pubmed-meshheading:3176062-Cell Differentiation,
pubmed-meshheading:3176062-Cell Transformation, Neoplastic,
pubmed-meshheading:3176062-Environmental Pollutants,
pubmed-meshheading:3176062-Humans,
pubmed-meshheading:3176062-Mathematics,
pubmed-meshheading:3176062-Models, Biological,
pubmed-meshheading:3176062-Neoplasms, Experimental,
pubmed-meshheading:3176062-Risk Factors
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
Biologically motivated two-stage model for cancer risk assessment.
|
|
pubmed:affiliation |
Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
