Linked Life Data

3174742

Source:http://linkedlifedata.com/resource/pubmed/id/3174742

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-10-31
pubmed:abstractText
Hippocampal rhythmic slow activity (RSA) was recorded during rotation and vibration stimulation after saline and ethanol (2 g/kg) administration in restrained alcohol-sensitive (ANT) and alcohol-insensitive (AT) rats implanted with chronic bipolar electrodes in the dorsal hippocampus. The saline-treated ANT rats had more high-frequency RSA than the AT rats, especially during the rotational stimulation of the optovestibular mechanisms. The difference was not found during ethanol sessions. Plasma corticosterone levels were significantly higher in the AT than the ANT rats after the recording sessions. This first electrophysiological demonstration of an alcohol-sensitivity difference in the brain between these rat lines is discussed in relation to behavioral tilting plane test used in the development of the lines, to the different innate responses of the lines to acute stress, and to the plausible line differences in brain GABAergic and serotonergic mechanisms that are known to modulate hippocampal EEG in rodents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Hippocampal rhythmic slow activity in rat lines selected for differences in ethanol-induced motor impairment.
pubmed:affiliation
Research Laboratories of the Finnish State Alcohol Company, Alko Ltd., Helsinki, Finland.
pubmed:publicationType
Journal Article, Comparative Study