Linked Life Data

3174732

Source:http://linkedlifedata.com/resource/pubmed/id/3174732

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-10-31
pubmed:abstractText
The effects of nicotine (NIC) and scopolamine (SCOP) on radial maze acquisition were examined using an 8-arm radial maze. In Experiment 1, food-deprived Sprague-Dawley rats were trained to eat food pellets located at the ends of each arm of the radial maze without repeating arm choices. Both NIC (0.45 mg/kg, SC) and SCOP (0.25 mg/kg, IP) impaired acquisition when they were administered before, but not after the daily training sessions. Experiment 2 examined the effect of nicotine on working and reference memory in rats trained to a criterion of 3 correct choices out of the first 4 choices with only 4 of the 8 arms baited. NIC (0.1-0.45 mg/kg) had no effect on working memory (reentry into baited arms) or reference memory (entry into unbaited arms) errors. It is concluded that NIC impairs processes involved in the acquisition but not maintenance of radial maze performance. Neither NIC nor SCOP affects post-training consolidation processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-22
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Nicotine impairs acquisition of radial maze performance in rats.
pubmed:affiliation
Department of Pharmacology, College of Medicine, University of Kentucky, Lexington 40536.
pubmed:publicationType
Journal Article