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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1988-11-23
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pubmed:abstractText |
The solid phase phospite triester synthesis of oligodeoxynucleotides containing cytosine arabinoside (araC) is described. A protected araC phosphoramadite was prepared for the introduction of araC residues at 5'termini and internucleotide positions in DNA oligomers. These oligomers were utilized to demonstrate the formation of correct 3'-5' linkages, to test for alkaline lability at the araC site, and to study the stability of duplexes containing araC-G base pairs. For the introduction of araC residues at 3' terminal positions, a protected derivative of araC was coupled to functionalized silica. This material was used to prepare a test oligomer which was characterized enzymatically.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-1057450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-14134442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-143235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-2453027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-2458756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-4292735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-5050364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-5799155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-6575837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-6942429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-7066295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-7200770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-7410404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3174449-911833
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9165-76
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1988
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pubmed:articleTitle |
Chemical synthesis of DNA oligomers containing cytosine arabinoside.
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pubmed:affiliation |
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06510.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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