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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1988-11-7
|
| pubmed:abstractText |
Distribution of leukocytes in rat mesenteric microvessel networks was studied using intravital fluorescence video microscopy. A digital image analysis system was used to measure vessel diameters, flow velocities and leukocyte fluxes in 306 capillaries of 8 networks. Capillaries were defined as vessel segments connecting divergent to convergent branch points. Their topological position within the network was quantified by a generation number defined as the number of bifurcations between the capillary and the arteriole feeding the network. Proximal capillaries (generation numbers 4 and 5) were slightly but significantly smaller in diameter (8.9 +/- 0.4 micron, mean +/- SEM) than distal ones (generation numbers 20 and 21, 10.1 +/- 0.4 micron). Average capillary flow velocity decreased markedly from 2.0 +/- 1.0 mm.s-1 in proximal to 0.41 +/- 0.06 mm.s-1 in distal capillaries. Average leukocyte concentration was 3.4 +/- 0.5.10(9) 1(-1) and thus significantly below systemic values (6.0.10(9) 1(-1] in proximal capillaries, and above in distal ones (11.7 +/- 2.6.10(9) 1(-1). The analysis of flow and leukocyte flux partition at 138 bifurcations showed preferential distribution of leukocytes to the daughter capillary with higher flow rate. This suggests a tentative explanation for the observed leukocyte accumulation along the microvascular tree: due to their low fractional flow, proximal capillaries draw relatively leukocyte-poor blood from the arteriole feeding the network; this leads to an increased leukocyte concentration in distal capillaries. As a consequence of the concomitant increase of capillary diameter with increasing generation number, leukocytes are preferentially flowing through larger capillaries and are excluded from small ones.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0031-6768
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
412
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
93-100
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3174389-Animals,
pubmed-meshheading:3174389-Capillaries,
pubmed-meshheading:3174389-Leukocytes,
pubmed-meshheading:3174389-Male,
pubmed-meshheading:3174389-Mesentery,
pubmed-meshheading:3174389-Microcirculation,
pubmed-meshheading:3174389-Microscopy, Fluorescence,
pubmed-meshheading:3174389-Rats,
pubmed-meshheading:3174389-Rats, Inbred Strains
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Preferential distribution of leukocytes in rat mesentery microvessel networks.
|
| pubmed:affiliation |
Department of Physiology, Freie Universität Berlin.
|
| pubmed:publicationType |
Journal Article
|