Linked Life Data

3174382

Source:http://linkedlifedata.com/resource/pubmed/id/3174382

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1988-11-7
pubmed:abstractText
Marked differences were observed in the intracellular electrical activities (spontaneous and TEA-induced) comparing the submucosal and myenteric plexus surfaces of the circular muscle of the dog colon. Distinct characteristics of the cells at the myenteric plexus surface were: a less (10 mV) polarized membrane, a lower amplitude slow wave, and the occurrence of burst type spiking activity. However, slow waves with a high upstroke amplitude (approximately 2.5 times higher than the plateau) were observed in 40% of the preparations. This high upstroke amplitude was dependent on the occurrence of a regenerative membrane potential change (a spike) during the slow wave propagation into the myenteric plexus surface. Such a spike was mediated by Ca2+-influx and could be evoked or enhanced by electrical pulses or by blocking a TEA-sensitive potassium conductance. In the presence of TEA, spikes occurred in bursts. Both slow waves and spiking activities generated contraction. In conclusion, at least two types of cells exist in the circular muscle layer with marked differences in electrophysiological properties. Slow waves are generated at the submucosal surface, passively propagated to the outermost circular muscle where they induce regenerative membrane potential changes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
412
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Heterogeneity in spontaneous and tetraethylammonium induced intracellular electrical activity in colonic circular muscle.
pubmed:affiliation
Intestinal Disease Research Unit, McMaster University, Hamilton, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't