Linked Life Data

3173404

Source:http://linkedlifedata.com/resource/pubmed/id/3173404

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1988-11-17
pubmed:abstractText
Exposure of preimplantation mouse embryos in culture to bromodeoxyuridine (BrdU) in the concentration range of 10(-9) to 2 x 10(-6) M allows sister-chromatid differentiation at the morula and blastocyst stage. The same BrdU concentrations induced no chromosomal aberrations, but a prolongation of the cell cycle and an increase of the SCE frequency. Even at the lowest BrdU concentration for sister-chromatid differentiation (10(-9) M the background level for SCE was found to be significantly higher in early embryos than in fetal or adult tissues of the mouse. Therefore, the high SCE frequency seems to be characteristic of undifferentiated embryonic cells. Methodological recommendations are also given for SCE assay in preimplantation mouse embryos.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0027-5107
pubmed:author
pubmed:issnType
Print
pubmed:volume
209
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Cytotoxic and genotoxic effects of bromodeoxyuridine during in vitro labelling for sister-chromatid differentiation in preimplantation mouse embryos.
pubmed:affiliation
Max von Pettenkofer Institute, Federal Health Office (BGA), Berlin (West), (F.R.G.).
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't