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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1988-11-18
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pubmed:abstractText |
The ability of 2,6-xylidine to produce chromosome breakage and/or spindle malformation in vivo was evaluated by an assessment of the capacity of the compound to induce micronuclei in bone marrow polychromatic erythrocytes. Male ICR mice were administered a single oral dose of 350, 175 or 87.5 mg/kg of 2,6-xylidine by oral gavage and bone marrow was extracted from the femurs 24, 48 and 72 h thereafter. The frequency of micronuclei in animals treated with 2,6-xylidine was not different from that observed for the corresponding solvent treated controls.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-5107
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
206
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
281-3
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3173395-Aniline Compounds,
pubmed-meshheading:3173395-Animals,
pubmed-meshheading:3173395-Bone Marrow,
pubmed-meshheading:3173395-Bone Marrow Cells,
pubmed-meshheading:3173395-Chromosome Aberrations,
pubmed-meshheading:3173395-Erythrocytes,
pubmed-meshheading:3173395-Male,
pubmed-meshheading:3173395-Mice,
pubmed-meshheading:3173395-Mice, Inbred ICR,
pubmed-meshheading:3173395-Mutagenicity Tests,
pubmed-meshheading:3173395-Mutagens,
pubmed-meshheading:3173395-Rats,
pubmed-meshheading:3173395-Rats, Inbred Strains
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pubmed:year |
1988
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pubmed:articleTitle |
The in vivo effect of 2,6-xylidine on induction of micronuclei in mouse bone marrow cells.
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pubmed:affiliation |
Toxicology Division, Division of Eli Lilly and Company, Greenfield, IN 46140.
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pubmed:publicationType |
Journal Article
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