Linked Life Data

3173265

Source:http://linkedlifedata.com/resource/pubmed/id/3173265

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1988-11-17
pubmed:abstractText
We examined the consequences of acute unilateral nephrectomy (AUN) on sodium (UNaV) and potassium excretion (UKV) in anesthetized rats which received either no volume replacement or an infusion of 1, 1.5, or 2% body weight of an albumin-saline solution during surgical preparation. Both UNaV and UKV during the initial control period increased progressively with graded volume repletion. AUN caused a significant increase in UNaV in each group, and the magnitude of this increment was related to the degree of volume repletion, and hence baseline UNaV: in rats replaced with 2% body weight of albumin-saline solution, UNaV rose from 1,801 +/- (SD) 260 to 3,435 +/- 1,748 nEq/min (p less than 0.005), while in rats receiving no replacement, it rose only from 213 +/- 106 to 469 +/- 186 nEq/min (p less than 0.005). In contrast, the increment in UKV was the same in each group despite higher baseline UKV related to graded volume repletion. In no group did GFR increase significantly. We conclude that volume expansion amplifies the natriuretic response to AUN by decreasing reabsorption in the proximal or distal nephron, or both. However, the postnephrectomy kaliuresis is not influenced by the degree of volume repletion, suggesting that it is mediated by a separate mechanism independent of volume expansion-induced changes in tubular function.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-0392
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-82
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Amplification of the natriuretic response to acute unilateral nephrectomy by volume expansion.
pubmed:affiliation
Division of Nephrology, San Francisco General Hospital, Calif.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't