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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1988-11-23
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pubmed:abstractText |
The antigenicity studies of a beta-lactam antibiotic, cefodizime sodium (THR-221), were examined in mice and guinea pigs and the following results were obtained. 1) In passive cutaneous anaphylaxis (PCA) with sera from BALB/c or C3H/He mice, a slight PCA reaction was observed only in BALB/c mice by using THR-221-ovalbumin (OVA) plus Freund's complete adjuvant (FCA) as the immunogen and THR-221 itself as the eliciting antigen. 2) Immunological cross-reactivity between THR-221 and CTX was present at the rat PCA reaction. 3) Antibodies against THR-221 were detected by PCA in guinea pigs. The anti-THR-221 antibodies gave PCA responses smaller than those of CMZ by using antibiotic plus FCA as the immunogen and the antibiotic-bovine serum albumin (BSA) as the eliciting antigen. 4) In the observation of active systemic anaphylaxis (ASA), no symptoms were observed in guinea pigs sensitized with THR-221 and provoked with THR-221-BSA. On the other hand, guinea pigs sensitized with THR-221 plus FCA by injecting THR-221-BSA showed fetal anaphylactic reactions. 5) The results of passive hemagglutination (PHA) also indicated that the PHA titer of THR-221 was lower than that of CMZ. 6) Protein binding property of THR-221 with human serum albumin was lower than other beta-lactam antibiotics. 7) Antibodies against THR-221-OVA by using THR-221-BSA as the eliciting antigen were detected in any tests above mentioned. It is concluded from these results that immunological activity of THR-221 was equivalent to the other beta-lactam antibiotics.
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pubmed:language |
jpn
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Cefotaxime,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin,
http://linkedlifedata.com/resource/pubmed/chemical/cefodizime
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0388-1350
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
13 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
231-43
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3172292-Anaphylaxis,
pubmed-meshheading:3172292-Animals,
pubmed-meshheading:3172292-Anti-Bacterial Agents,
pubmed-meshheading:3172292-Antibodies,
pubmed-meshheading:3172292-Antigens,
pubmed-meshheading:3172292-Cefotaxime,
pubmed-meshheading:3172292-Cross Reactions,
pubmed-meshheading:3172292-Guinea Pigs,
pubmed-meshheading:3172292-Hemagglutination Tests,
pubmed-meshheading:3172292-Male,
pubmed-meshheading:3172292-Mice,
pubmed-meshheading:3172292-Mice, Inbred BALB C,
pubmed-meshheading:3172292-Mice, Inbred C3H,
pubmed-meshheading:3172292-Passive Cutaneous Anaphylaxis,
pubmed-meshheading:3172292-Protein Binding,
pubmed-meshheading:3172292-Rats,
pubmed-meshheading:3172292-Rats, Inbred Strains,
pubmed-meshheading:3172292-Serum Albumin
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pubmed:year |
1988
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pubmed:articleTitle |
[Antigenicity test of cefodizime sodium].
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pubmed:affiliation |
Daiichi Pure Chemicals Co. Ltd., Tokai Research Laboratories, Tokai-mura Ibaraki-ken, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
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