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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1988-11-18
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pubmed:abstractText |
The synthesis of a series of novel 4,5-dihydro-4-oxo-2-(substituted amino)-3-furancarboxylic acids, salts, esters, and amides is described. The title compounds when tested in the mediator-induced dermal vascular permeability and active anaphylaxis assays in rats demonstrated moderate to potent antiallergic activity. The [2-trans-(4-methylphenyl)cyclopropyl]amino analogue 53 emerged as the most active derivative. Thus, when administered intraperitoneally to rats at a dose of 100 mg/kg, it inhibited the action of the mediators serotonin, histamine, and bradykinin by 100%. In the active anaphylaxis assay in rats, compound 30 suppressed the edema by 81% at a dose of 100 mg/kg, following intraperitoneal administration.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-2623
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1910-8
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3172125-Animals,
pubmed-meshheading:3172125-Antibody Formation,
pubmed-meshheading:3172125-Bradykinin,
pubmed-meshheading:3172125-Capillary Permeability,
pubmed-meshheading:3172125-Furans,
pubmed-meshheading:3172125-Histamine,
pubmed-meshheading:3172125-Hypersensitivity,
pubmed-meshheading:3172125-Rats,
pubmed-meshheading:3172125-Serotonin,
pubmed-meshheading:3172125-Structure-Activity Relationship
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pubmed:year |
1988
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pubmed:articleTitle |
Drug-induced modifications of the immune response. 12. 4,5-Dihydro-4-oxo-2-(substituted amino)-3-furancarboxylic acids and derivatives as novel antiallergic agents.
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pubmed:affiliation |
Department of Organic Chemistry, Pennwalt Corporation, Rochester, New York 14623.
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pubmed:publicationType |
Journal Article
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