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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1988-11-4
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pubmed:abstractText |
To verify the potential in vivo inhibitory effect on liver function of tumor necrosis factor (TNF), also known as cachectin, antipyrine and diazepam were chosen to probe the hepatic mixed-function oxidase system. A single dose of TNF (30 micrograms/kg) to rats significantly reduced the plasma clearance of antipyrine and diazepam by about 30% and 25%, respectively; this resulted in concomitant prolongation of the elimination half-life (t1/2) of the two drugs, although of borderline significance for the benzodiazepine. This was probably due to a decrease in hepatic cytochrome P-450 activities that are responsible for antipyrine and diazepam metabolism in TNF-treated rats. This could be of clinical relevance if a similar effect occurs in humans after therapeutically effective doses of this biological response modifier.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0732-6580
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
7
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
365-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3171600-Animals,
pubmed-meshheading:3171600-Antipyrine,
pubmed-meshheading:3171600-Diazepam,
pubmed-meshheading:3171600-Liver,
pubmed-meshheading:3171600-Male,
pubmed-meshheading:3171600-Rats,
pubmed-meshheading:3171600-Recombinant Proteins,
pubmed-meshheading:3171600-Tumor Necrosis Factor-alpha
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pubmed:year |
1988
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pubmed:articleTitle |
Recombinant tumor necrosis factor reduces hepatic drug metabolism in vivo in the rat.
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pubmed:affiliation |
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro
|