Linked Life Data

3171243

Source:http://linkedlifedata.com/resource/pubmed/id/3171243

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-11-23
pubmed:abstractText
The pharmacokinetics of recombinant human interferon-alpha I (rHuIFN-alphaI) were studied following a single 3 X 10(6) U/kg dose administered as a 30-min intravenous (iv) infusion and as an intramuscular (im) injection to four African green monkeys using a crossover design. Concentrations of rHuIFN-alpha I in serum were determined by bioassay. Serum rHuIFN-alpha I concentrations declined rapidly following an iv infusion. The elimination half-life ranged from 1.7 to 2.0 h. The volume of distribution at steady state and the total body clearance ranged from 0.42 to 2.4 L/kg and 28 to 233 ml/min, respectively. A protracted absorption profile was seen following im injection, with a highly variable bioavailability ranging from 16 to 680%, compared with the iv infusion. The overall disposition of rHuIFN-alpha I is comparable to that of rHuIFN-alpha A and other IFNs in monkeys.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0197-8357
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
427-32
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Pharmacokinetics of human recombinant interferon-alpha I after i.v. infusion and im injection in African green monkeys.
pubmed:affiliation
Hoffmann-La Roche Inc., Nutley, NJ 07110.
pubmed:publicationType
Journal Article