Linked Life Data

316989

Source:http://linkedlifedata.com/resource/pubmed/id/316989

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1980-4-23
pubmed:abstractText
A study of the susceptibility to cefotaxime and six other cephalosporins in 213 nonselected strains of nine different bacterial species clearly showed that cefotaxime was the most active against aerobic gram-negative bacilli. The same pattern emerged with 84 cephalothin-resistant strains of five enterobacterial species, but the mean minimal inhibitory concentration values for all cephalosporins were about twofold higher in this group of strains. Cephalothin was the most active antibiotic against Staphylococcus aureus. The inoculus effect of 10 cephalothin-resistant strains was relatively small, but it was most marked for cefamandole, as compared with that of three other new cephalosporins, including cefotaxime. The susceptibility of these cephalosporins to beta-lactamases from 12 beta-lactamase-producing enterobacterial strains was determined. Half of these were slightly active against cefotaxime and had similar activity against cefuroxime. Cefoxitin was not degraded at all, and cefamandole was the most susceptible. No correlation between beta-lactamase susceptibility and minimal inhibitory concentration values of different cephalosporins was found. Cefotaxime combined high intrinsic antibiotic activity with marked resistance to beta-lactamase inactivation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/316989-1259407, http://linkedlifedata.com/resource/pubmed/commentcorrection/316989-308505, http://linkedlifedata.com/resource/pubmed/commentcorrection/316989-308506, http://linkedlifedata.com/resource/pubmed/commentcorrection/316989-311615, http://linkedlifedata.com/resource/pubmed/commentcorrection/316989-349097, http://linkedlifedata.com/resource/pubmed/commentcorrection/316989-426518, http://linkedlifedata.com/resource/pubmed/commentcorrection/316989-4599124, http://linkedlifedata.com/resource/pubmed/commentcorrection/316989-4790616, http://linkedlifedata.com/resource/pubmed/commentcorrection/316989-4840447, http://linkedlifedata.com/resource/pubmed/commentcorrection/316989-742875, http://linkedlifedata.com/resource/pubmed/commentcorrection/316989-802124
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
757-60
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Comparison of activity and beta-lactamase stability of cefotaxime with those of six other cephalosporins.
pubmed:publicationType
Journal Article, Comparative Study