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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
1988-11-4
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pubmed:abstractText |
The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti-HIV activity [(1987) Proc. Natl. Acad. Sci. USA 84, 8120-8124; (1987) Nature 330, 74-77; (1987) Lancet i, 1025-1026]. They are thought to act by inhibiting alpha-glucosidase I, an enzyme involved in the processing of N-linked oligosaccharides on glycoproteins. We report here the relative efficacy of a spectrum of amino-sugar derivatives as inhibition of HIV cytopathicity. Several alpha-glucosidase inhibitors and alpha-fucosidase inhibitors were found to be active at concentrations which were non-cytotoxic.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0014-5793
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
12
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pubmed:volume |
237
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
128-32
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3169233-Amino Sugars,
pubmed-meshheading:3169233-Cell Line,
pubmed-meshheading:3169233-DNA Replication,
pubmed-meshheading:3169233-HIV,
pubmed-meshheading:3169233-HIV-1,
pubmed-meshheading:3169233-HIV-2,
pubmed-meshheading:3169233-Humans,
pubmed-meshheading:3169233-Molecular Structure,
pubmed-meshheading:3169233-Structure-Activity Relationship,
pubmed-meshheading:3169233-Virus Replication
|
pubmed:year |
1988
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pubmed:articleTitle |
Inhibition of HIV replication by amino-sugar derivatives.
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pubmed:affiliation |
Dyson Perrins Laboratory, Department of Organic Chemistry, University of Oxford, England.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|