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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1988-11-18
|
| pubmed:abstractText |
Ifosfamide (IF) pharmacokinetics and the plasma (NBP)-alkylating activity were determined in 33 patients with different tumours after the administration of IF as single-agent chemotherapy. All subjects had been phenotyped for debrisoquine oxidation. There is a lack of correlation between the debrisoquine metabolic ratio (DMR) and either the total plasma clearance of IF (CLIF) or the AUC of the plasma NBP-alkylating activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0344-5704
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
321-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3168145-Adult,
pubmed-meshheading:3168145-Aged,
pubmed-meshheading:3168145-Alkylation,
pubmed-meshheading:3168145-Debrisoquin,
pubmed-meshheading:3168145-Female,
pubmed-meshheading:3168145-Humans,
pubmed-meshheading:3168145-Ifosfamide,
pubmed-meshheading:3168145-Isoquinolines,
pubmed-meshheading:3168145-Male,
pubmed-meshheading:3168145-Middle Aged,
pubmed-meshheading:3168145-Neoplasms,
pubmed-meshheading:3168145-Oxidation-Reduction,
pubmed-meshheading:3168145-Polymorphism, Genetic
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Ifosfamide plasma clearance in relation to polymorphic debrisoquine oxidation.
|
| pubmed:affiliation |
Department of Clinical Pharmacology, United Medical School, Guy's Hospital, London Bridge, U.K.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|