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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1988-8-8
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pubmed:abstractText |
Phorbol 12-myristate 13-acetate (PMA) induces the differentiation of the human promyelocytic cell line, HL60, towards adherent macrophage-like cells within 2 days. We have examined the early effects of PMA on inositol phosphates and on diacylglycerol production, two second messengers derived from inositol lipids. In proliferating HL60 cells, PMA induced a time- and concentration-dependent decrease in inositol phosphate levels. Maximal effects were seen after 1 h at 10 nM PMA. PMA also induced the translocation of protein kinase C from the cytosol to the membrane. Comparison between the differentiating effects of several phorbol esters and of 1-oleoyl-2-acetylglycerol with their ability to inhibit inositol phosphate formation suggests that the two effects are correlated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
233
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
239-43
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3164278-Cell Differentiation,
pubmed-meshheading:3164278-Cell Line,
pubmed-meshheading:3164278-Diglycerides,
pubmed-meshheading:3164278-Glycerides,
pubmed-meshheading:3164278-Humans,
pubmed-meshheading:3164278-Inositol Phosphates,
pubmed-meshheading:3164278-Kinetics,
pubmed-meshheading:3164278-Leukemia, Myeloid, Acute,
pubmed-meshheading:3164278-Phorbol Esters,
pubmed-meshheading:3164278-Structure-Activity Relationship,
pubmed-meshheading:3164278-Sugar Phosphates,
pubmed-meshheading:3164278-Tetradecanoylphorbol Acetate
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pubmed:year |
1988
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pubmed:articleTitle |
Phorbol esters inhibit inositol phosphate and diacylglycerol formation in proliferating HL60 cells. Relationship to differentiation.
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pubmed:affiliation |
INSERM, Unité 204, Hopital Saint Louis, Paris, France.
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pubmed:publicationType |
Journal Article
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