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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1980-3-17
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pubmed:abstractText |
The response of differentiating MEL cells to the nucleotide analogue cordycepin reveals a previously unrecognized aspect of the molecular events which cause commitment of these cells to terminal erythroid differentiation. Cordycepin rapidly inhibits commitment of DMSO-treated MEL cells in a dose range which does not cause cytotoxicity. Reversal of cordycepin treatment in the presence of inducer leads to a rapid and synchronous commitment of a significant proportion of cells in the culture. These results suggest that MEL cells can be blocked just prior to the point of commitment by cordycepin treatment.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
pubmed:issn |
0092-8674
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1073-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:316363-Animals,
pubmed-meshheading:316363-Cell Differentiation,
pubmed-meshheading:316363-Cell Division,
pubmed-meshheading:316363-Cell Line,
pubmed-meshheading:316363-Deoxyadenosines,
pubmed-meshheading:316363-Dimethyl Sulfoxide,
pubmed-meshheading:316363-Erythropoiesis,
pubmed-meshheading:316363-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:316363-Mice,
pubmed-meshheading:316363-RNA
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pubmed:year |
1979
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pubmed:articleTitle |
Synchronization of MEL cell commitment with cordycepin.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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