Linked Life Data

3162711

Source:http://linkedlifedata.com/resource/pubmed/id/3162711

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1988-5-18
pubmed:abstractText
The effects of 4-hydroperoxycyclophosphamide (4-HC), an analogue of cyclophosphamide, on the blast progenitors from eight acute myeloblastic leukemia patients were studied in methylcellulose and suspension cultures. Leukemic blast progenitors undergo terminal divisions in methylcellulose culture, making blast colonies. Cells in primary colonies can make secondary colonies after replating in fresh methylcellulose medium. Leukemic blast progenitors grow exponentially in suspension culture for periods of weeks. The ability to form secondary colonies and the exponential growth in suspension culture are considered to reflect the self-renewal of blast progenitors. 4-HC suppressed primary blast colonies in a dose-responsive manner. Secondary colonies were not significantly affected by 4-HC. Although the clonogenic cell recovery was suppressed by 4-HC, leukemic blast progenitors were less sensitive to 4-HC in suspension culture than in methylcellulose culture. The results suggest that 4-HC is effective in suppressing the terminal divisions of blast progenitors but not as effective against the self-renewal of blast progenitors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2348-52
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Cytotoxicity of 4-hydroperoxycyclophosphamide for the blast progenitors of acute myeloblastic leukemia.
pubmed:affiliation
First Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't