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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1988-4-22
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pubmed:abstractText |
Sixty-two women with advanced breast cancer were admitted to a pilot study in which a modified CMF regimen was administered. Cyclophosphamide was administered i.v. at a dosage of 600 mg/m2 on the same day as fluorouracil (600 mg/m2/i.v.) and methotrexate (40 mg/m2/i.v.). The therapy was recycled on the 21st day and in the presence of myelosuppression, the administration of the drugs was delayed for 1-2 weeks recovery of the hematologic values. CR + PR were obtained in 42% of patients and no change in 32% (U.I.C.C. criteria). Metastases to soft tissues showed CR + PR in 55% of the cases, bone in 33% and viscera in 35%. The menopausal status, the disease-free interval and the number of involved sites did not influence statistically the percentage of responses; however, the response rate was influenced statistically by previous treatment. The median duration of response was 7.5 months; the median overall survival of the 60 evaluable patients was 18 months. Due to myelosuppression, CMF i.v. administration was delayed 90/620 times (14%). Toxicity was acceptable and had a lower incidence than that reported in the literature in different series of CMF administered p.o. Nausea and vomiting, in particular, were limited to 24-48 h after administration of the drugs, and alopecia was seldom observed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0300-8916
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-63
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pubmed:dateRevised |
2008-12-12
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pubmed:meshHeading |
pubmed-meshheading:3162624-Administration, Oral,
pubmed-meshheading:3162624-Bone Neoplasms,
pubmed-meshheading:3162624-Breast Neoplasms,
pubmed-meshheading:3162624-Daunorubicin,
pubmed-meshheading:3162624-Drug Evaluation,
pubmed-meshheading:3162624-Female,
pubmed-meshheading:3162624-Humans,
pubmed-meshheading:3162624-Idarubicin,
pubmed-meshheading:3162624-Remission Induction,
pubmed-meshheading:3162624-Soft Tissue Neoplasms
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pubmed:year |
1988
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pubmed:articleTitle |
Intravenous administration of cyclophosphamide, methotrexate and 5-fluorouracil in metastatic breast cancer. A pilot study.
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pubmed:affiliation |
Oncologic Institute, Bari, Italia.
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pubmed:publicationType |
Journal Article
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