Linked Life Data

3162438

Source:http://linkedlifedata.com/resource/pubmed/id/3162438

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-5-2
pubmed:abstractText
By following the interaction of labelled anti-tumor antibodies with target cells, it was found that in most systems cross-linking of externally bound antibody by anti-IgG leads to nearly complete internalization, whereas excess unlabelled antibody induces fast release of radioactivity from the cell. Uptake in tumor tissue did not depend on presentation of antigen at the cell surface, as demonstrated with antibody RA96 directed against an intra- and inter-cellular antigen. With respect to permeation into solid tissue, autoradiography revealed highly non-homogeneous distribution of intact IgG, while antibody fragments tended to show a more homogeneous penetration. Small spontaneous metastases showed markedly higher accumulation than large tumor processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0898-6924
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-4
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Dynamics of antibody transport and internalization.
pubmed:affiliation
Institute of Nuclear Medicine, German Cancer Research Center, Heidelberg.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't