Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-9-16
pubmed:abstractText
This study characterizes the T helper (Th) cells that initiate primary cytotoxic T lymphocyte (CTL) responses against allogeneic and trinitrophenyl (TNP)-modified self class I major histocompatibility (MHC) determinants. We show that two distinct Th cell subsets participate in allospecific CTL responses: (a) an L3T4+,Lyt-2- class II-restricted Th cell population, and (b) an L3T4-,Lyt-2+ class I-restricted Th cell population. Both of these T cell subpopulations were shown to function in allospecific CTL responses as helper cells by their ability to show synergy with allospecific CTL precursors. Thus, primary class I allospecific CTL responses represent an immune response involving not only L3T4+ Th cells, but Lyt-2+ Th cells as well. One of the necessary functions performed by both L3T4+ and Lyt-2+ Th cell populations in allospecific CTL responses was found to be the secretion of interleukin 2. Finally, despite the many similarities between anti-allo- and anti-TNP-CTL responses, anti-TNP-CTL responses were found to be mediated by only L3T4+ Th cells, not by Lyt-2+ Th cells. Consequently, Lyt-2+ Th cells appear to be a helper cell population that is primarily involved in MHC-specific immune responses.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-100571, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-214510, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-300484, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-310839, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-387874, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-4122709, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-415885, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-4542806, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-4547153, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-53263, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6154084, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6157731, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6162887, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6166716, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6184397, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6195085, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6201534, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6203969, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6206144, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6217271, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6412230, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6460073, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6604748, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6935293, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6969401, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6976516, http://linkedlifedata.com/resource/pubmed/commentcorrection/3160804-6979580
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
162
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
427-43
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self.
pubmed:publicationType
Journal Article