Linked Life Data

3160237

Source:http://linkedlifedata.com/resource/pubmed/id/3160237

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-8-6
pubmed:abstractText
An earlier report showed significant differences among Huntington disease (HD) patients, controls, and particular age cohorts of at-risk persons for several dimensions of body mass and for several linear and craniofacial components of the body. In this investigation a function was derived from a stepwise discriminant analysis of the affected and unaffected groups, and used to classify the at-risk individuals according to HD gene carrier status. The function, comprised of body mass index, subscapular skinfold, head length, and sitting height, classified 95% of the controls and 87% of the affected individuals correctly. Approximately 80% of the individuals at-risk were classified with 80% or greater certainty. We propose that anthropometric variables may prove to be a powerful tool for basic research in HD and the derived discriminant function has potential clinical value as a diagnostic and preclinical diagnostic aid. We emphasize that corroborative testing on other sample populations of HD families is required before these techniques are utilized. Also, it is imperative that the anthropometric protocol include appropriate standardization of the raw measurement data.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0148-7299
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
307-16
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Anthropometric discrimination among affected, at-risk, and not-at-risk individuals in families with Huntington disease.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't