Linked Life Data

3157352

Source:http://linkedlifedata.com/resource/pubmed/id/3157352

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1985-5-10
pubmed:abstractText
Using Charles River-SD 7-week-old rats, a study was carried out on the immunological changes resulting from localized intrahepatic injection of Adriamycin (ADM). The subjects were categorized into groups injected with either saline solution, ADM-0.5mg/kg, ADM-1.0mg/kg or ADM-2.0mg/kg. Measurements were undertaken prior to injection, on the first day and on the fifth day after injection through cardiac blood sampling to determine the absolute counts of T-cells, B-cells, helper T-cells, and suppressor T-cells. On comparing these values in the saline group to the ADM groups prior to the ADM groups prior to the first day. By the fifth day, however, significant differences were evident between changes which had occurred in the two groups. When changes in the saline group and the ADM-0.5 group were studied prior to localized intrahepatic injection on the fifth day, there no significant differences. The ADM-1.0 group and the ADM-2.0 group showed a decline in T-cells (P less than 0.05) with no changes in B-cells, Th-cells or Ts-cells. As shown above, when the liver was injected with saline, no immunological changes were recognized. On the other hand, reduction in T-cells was ascertained when ADM was injected.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0385-0684
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
907-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
[Immunological study on localized intrahepatic injection of Adriamycin--experimental study in rats].
pubmed:publicationType
Journal Article, English Abstract