| pubmed-article:3156868 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3156868 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:3156868 | lifeskim:mentions | umls-concept:C1704336 | lld:lifeskim |
| pubmed-article:3156868 | lifeskim:mentions | umls-concept:C0001041 | lld:lifeskim |
| pubmed-article:3156868 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:3156868 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:3156868 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:3156868 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:3156868 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:3156868 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:3156868 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:3156868 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3156868 | pubmed:dateCreated | 1985-5-10 | lld:pubmed |
| pubmed-article:3156868 | pubmed:abstractText | We have examined acetylcholine (ACh)-elicited potentials or currents in current- or voltage-clamped cultured myotubes exposed to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a potent tumor promoter that activates protein kinase C. Although this agent had little action on either membrane resting potential or electrical resistance, a reversible decrease in ACh sensitivity was induced on 3-4-d-old chick myotubes. Depression of transmitter action by TPA was extended to 7-8-d mouse myotubes only when they were treated with phosphatidylserine. Glyceryl dioleate had effects on myotubes similar to those of TPA but with a reduced efficacy. We conclude that the activation of protein kinase C might be involved with the capacity of ACh receptors to respond to transmitter stimulation. | lld:pubmed |
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| pubmed-article:3156868 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3156868 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3156868 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3156868 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3156868 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:3156868 | pubmed:author | pubmed-author:EusebiFF | lld:pubmed |
| pubmed-article:3156868 | pubmed:author | pubmed-author:MolinaroMM | lld:pubmed |
| pubmed-article:3156868 | pubmed:author | pubmed-author:ZaniB MBM | lld:pubmed |
| pubmed-article:3156868 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3156868 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:3156868 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3156868 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3156868 | pubmed:pagination | 1339-42 | lld:pubmed |
| pubmed-article:3156868 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:3156868 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3156868 | pubmed:articleTitle | Agents that activate protein kinase C reduce acetylcholine sensitivity in cultured myotubes. | lld:pubmed |
| pubmed-article:3156868 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3156868 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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