|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1985-5-10
|
|
pubmed:abstractText |
We have examined acetylcholine (ACh)-elicited potentials or currents in current- or voltage-clamped cultured myotubes exposed to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a potent tumor promoter that activates protein kinase C. Although this agent had little action on either membrane resting potential or electrical resistance, a reversible decrease in ACh sensitivity was induced on 3-4-d-old chick myotubes. Depression of transmitter action by TPA was extended to 7-8-d mouse myotubes only when they were treated with phosphatidylserine. Glyceryl dioleate had effects on myotubes similar to those of TPA but with a reduced efficacy. We conclude that the activation of protein kinase C might be involved with the capacity of ACh receptors to respond to transmitter stimulation.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-13449877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-13984697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-14422355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-177216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-179836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-375254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-397370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-526298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-6146314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-6190556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-6232463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-6280056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-6311189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-6324252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-6406488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-6543903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-6604155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-667602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-6700633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-6873465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-7035257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-7067943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-7085651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-7122574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-7251589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-7358670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156868-894536
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0021-9525
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
100
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1339-42
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:3156868-Acetylcholine,
pubmed-meshheading:3156868-Animals,
pubmed-meshheading:3156868-Cells, Cultured,
pubmed-meshheading:3156868-Chick Embryo,
pubmed-meshheading:3156868-Electrophysiology,
pubmed-meshheading:3156868-Enzyme Activation,
pubmed-meshheading:3156868-Membrane Potentials,
pubmed-meshheading:3156868-Mice,
pubmed-meshheading:3156868-Muscles,
pubmed-meshheading:3156868-Phorbols,
pubmed-meshheading:3156868-Protein Kinase C,
pubmed-meshheading:3156868-Protein Kinases,
pubmed-meshheading:3156868-Receptors, Cholinergic,
pubmed-meshheading:3156868-Tetradecanoylphorbol Acetate
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Agents that activate protein kinase C reduce acetylcholine sensitivity in cultured myotubes.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
