|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1985-5-20
|
|
pubmed:abstractText |
Previous studies have shown that monoclonal antibody AF3.44.4 has specificity for a constant region determinant on mouse antigen-specific helper factors and that it also binds to cultured T cells with functional helper cell characteristics. The antibody synergizes with antigen to enhance in vitro antibody responses; here we demonstrate that it will also enhance cell-mediated responses in vitro such as in the generation of proliferating cells in mixed lymphocyte responses and in the generation of specific killer cells in cytotoxic T lymphocyte cultures. The mechanism of AF3.44.4-generated enhancement was investigated. Increased levels of the lymphokines IL-2 and BCDF were detected in supernatants of AF3.44.4-treated cultures but the antibody itself could not replace interleukin-2 (IL-2), and would not stimulate primed cells in the absence of antigen. This type of monoclonal antibody which augments immunological responses in an antigen-dependent fashion may provide a new class of immunostimulant and a new approach to augmenting the responses of weak immunogens.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-1094630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-1172191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-307029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-5653817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6142077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6185617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6187814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6193236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6218408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6231105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-62667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6319271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6460641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6460688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6600241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6601175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6790656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6797272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6798123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6965968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-6976516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3156808-94504
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0019-2805
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
693-700
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3156808-Animals,
pubmed-meshheading:3156808-Antibodies, Monoclonal,
pubmed-meshheading:3156808-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:3156808-Antigens, Surface,
pubmed-meshheading:3156808-Cytotoxicity, Immunologic,
pubmed-meshheading:3156808-Immunity, Cellular,
pubmed-meshheading:3156808-Interleukin-2,
pubmed-meshheading:3156808-Isoantibodies,
pubmed-meshheading:3156808-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:3156808-Mice,
pubmed-meshheading:3156808-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:3156808-T-Lymphocytes, Helper-Inducer
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Augmentation of cell-mediated responses in vitro by a monoclonal anti-helper factor antibody.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
